| 1. Round | 08/08/2020 | FK Senica | - | MŠK Žilina | 0:4 | ||||
| 2. Round | 11/08/2020 | MŠK Žilina | - | FC Nitra | 1:2 | ||||
| 3. Round | 15/08/2020 | AS Trenčín | - | MŠK Žilina | 2:4 | ||||
| 4. Round | 22/08/2020 | FK Pohronie | - | MŠK Žilina | 2:1 | ||||
| 5. Round | 30/08/2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 |  |
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| 6. Round | 12/09/2020 | ŠKF Sereď | - | MŠK Žilina | 3:2 | ||||
| 7. Round | 20/09/2020 | MŠK Žilina | - | Slovan Bratislava | 2:2 | ||||
| 8. Round | 26/09/2020 | Zlaté Moravce | - | MŠK Žilina | 4:0 | ||||
| 9. Round | 03/10/2020 | MŠK Žilina | - | FC DAC 1904 | 4:1 | ||||
| 10. Round | 18/10/2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Round | 24/10/2020 | MFK Ružomberok | - | MŠK Žilina | 2:1 | ||||
| 12. Round | 31/10/2020 | MŠK Žilina | - | FK Senica | 3:1 | ||||
| 18. Round | 16/12/2020 | Slovan Bratislava | - | MŠK Žilina | 3:2 | ||||
| 21. Round | 27/02/2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | ||||
| 22. Round | 06/03/2021 | MŠK Žilina | - | MFK Ružomberok | 3:2 | |
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Slovakia