| 1. Round | 25/07/2021 | MŠK Žilina | - | ŠKF Sereď | 3:0 |  |
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| 2. Round | 01/08/2021 | Zlaté Moravce | - | MŠK Žilina | 0:1 | ||||
| 4. Round | 15/08/2021 | Tatran Liptovský Mikuláš | - | MŠK Žilina | 2:1 | |
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| 5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 |  |
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| 6. Round | 29/08/2021 | Spartak Trnava | - | MŠK Žilina | 1:1 | ||||
| 7. Round | 11/09/2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 9. Round | 25/09/2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
| 17. Round | 05/12/2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
| 18. Round | 11/12/2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 20. Round | 14/02/2022 | MFK Ružomberok | - | MŠK Žilina | 5:1 | ||||
| 21. Round | 19/02/2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 |
Slovakia