| 1. Round | 16/07/2022 | AS Trenčín | - | MŠK Žilina | 0:0 | ||||
| 2. Round | 24/07/2022 | MŠK Žilina | - | FC DAC 1904 | 1:1 |  |
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| 3. Round | 29/07/2022 | MŠK Žilina | - | Dukla Banská Bystrica | 4:1 | |
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| 4. Round | 07/08/2022 | Spartak Trnava | - | MŠK Žilina | 2:2 | ||||
| 5. Round | 13/08/2022 | MŠK Žilina | - | Zlaté Moravce | 1:0 | ||||
| 6. Round | 21/08/2022 | Slovan Bratislava | - | MŠK Žilina | 3:1 | ||||
| 7. Round | 26/08/2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:0 | |
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| 8. Round | 30/08/2022 | MFK Skalica | - | MŠK Žilina | 1:0 | ||||
| 9. Round | 02/09/2022 | MŠK Žilina | - | FK Železiarne Podbrezová | 0:1 | ||||
| 10. Round | 09/09/2022 | MFK Ružomberok | - | MŠK Žilina | 0:2 | ||||
| 11. Round | 17/09/2022 | MŠK Žilina | - | Tatran Liptovský Mikuláš | 4:2 |  |
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| 12. Round | 01/10/2022 | MŠK Žilina | - | AS Trenčín | 1:1 | ||||
| 13. Round | 09/10/2022 | FC DAC 1904 | - | MŠK Žilina | 5:2 | ||||
| 14. Round | 15/10/2022 | Dukla Banská Bystrica | - | MŠK Žilina | 2:1 | |
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| 15. Round | 22/10/2022 | MŠK Žilina | - | Spartak Trnava | 1:2 | ||||
| 16. Round | 28/10/2022 | Zlaté Moravce | - | MŠK Žilina | 4:0 | ||||
| 17. Round | 06/11/2022 | MŠK Žilina | - | Slovan Bratislava | 4:1 | ||||
| 18. Round | 12/11/2022 | MFK Zemplín Michalovce | - | MŠK Žilina | 3:2 | |
Slovakia