| 1. Round | 14/03/2022 | FC Botoşani | - | Gaz Metan Mediaş | 5:0 |  |
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| 2. Round | 19/03/2022 | Gaz Metan Mediaş | - | FC Universitatea Craiova | 0:2 | ||||
| 3. Round | 02/04/2022 | UTA Arad | - | Gaz Metan Mediaş | 4:0 | ||||
| 4. Round | 11/04/2022 | Gaz Metan Mediaş | - | CS Mioveni | 1:2 | ||||
| 5. Round | 18/04/2022 | Rapid Bucureşti | - | Gaz Metan Mediaş | 8:0 | ||||
| 6. Round | 22/04/2022 | Gaz Metan Mediaş | - | Dinamo Bucureşti | 0:1 | ||||
| 7. Round | 29/04/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 3:1 | |
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| 8. Round | 06/05/2022 | Gaz Metan Mediaş | - | Academica Clinceni | 4:3 | ||||
| 9. Round | 13/05/2022 | Chindia Târgoviște | - | Gaz Metan Mediaş | 3:0 |
Romania