| 1. Round | 06/08/2005 | Swansea City | - | Tranmere Rovers | 1:0 | ||||
| 2. Round | 09/08/2005 | Tranmere Rovers | - | Blackpool FC | 2:2 |  |
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| 3. Round | 12/08/2005 | Tranmere Rovers | - | Oldham Athletic | 4:0 | ||||
| 4. Round | 20/08/2005 | Brentford FC | - | Tranmere Rovers | 2:0 | ||||
| 15. Round | 22/10/2005 | Tranmere Rovers | - | Colchester United | 0:0 | |
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| 16. Round | 29/10/2005 | Doncaster Rovers | - | Tranmere Rovers | 0:2 | ||||
| 17. Round | 12/11/2005 | Tranmere Rovers | - | Milton Keynes Dons | 1:2 | ||||
| 18. Round | 19/11/2005 | Scunthorpe United | - | Tranmere Rovers | 1:2 | |
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| 23. Round | 26/12/2005 | Walsall FC | - | Tranmere Rovers | 0:0 | ||||
| 24. Round | 28/12/2005 | Tranmere Rovers | - | Yeovil Town | 4:1 | ||||
| 29. Round | 21/01/2006 | Tranmere Rovers | - | Southend United | 0:0 | ||||
| 35. Round | 25/02/2006 | Oldham Athletic | - | Tranmere Rovers | 1:0 | ||||
| 45. Round | 29/04/2006 | Milton Keynes Dons | - | Tranmere Rovers | 1:2 | ||||
| 46. Round | 06/05/2006 | Tranmere Rovers | - | Doncaster Rovers | 0:2 | |
England