| 1. Round | 25/07/2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
| 2. Round | 31/07/2021 | FK Pohronie | - | MFK Zemplín Michalovce | 2:0 | ||||
| 3. Round | 08/08/2021 | MŠK Žilina | - | FK Pohronie | 3:1 |  |
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| 4. Round | 14/08/2021 | FK Pohronie | - | ŠKF Sereď | 1:1 | |
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| 5. Round | 20/08/2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
| 6. Round | 27/08/2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 7. Round | 11/09/2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 9. Round | 24/09/2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 10. Round | 03/10/2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
| 16. Round | 27/11/2021 | FK Pohronie | - | Zlaté Moravce | 0:2 | ||||
| 17. Round | 04/12/2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 |
Czech Republic