| 1. Round | 20/08/2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 2. Round | 24/08/2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Round | 12/09/2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 5. Round | 25/09/2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Round | 03/10/2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 |  |
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| 9. Round | 03/11/2021 | Mamelodi Sundowns | - | Maritzburg United | 1:0 | ||||
| 10. Round | 07/11/2021 | Marumo Gallants | - | Mamelodi Sundowns | 0:4 | |
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| 19. Round | 24/11/2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 12. Round | 27/11/2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 | ||||
| 13. Round | 04/12/2021 | Stellenbosch FC | - | Mamelodi Sundowns | 1:1 | ||||
| 22. Round | 14/12/2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 | ||||
| 16. Round | 17/12/2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | |
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| 17. Round | 20/12/2021 | AmaZulu FC | - | Mamelodi Sundowns | 1:0 | ||||
| 8. Round | 14/02/2022 | Baroka FC | - | Mamelodi Sundowns | 1:1 | ||||
| 25. Round | 12/04/2022 | Mamelodi Sundowns | - | Golden Arrows | 6:0 | |
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| 29. Round | 14/05/2022 | Mamelodi Sundowns | - | Stellenbosch FC | 0:3 |
Slovakia