| 16. Round | 28/11/2021 | Legia Warszawa | - | Jagiellonia Białystok | 1:0 | ||||
| 17. Round | 04/12/2021 | Jagiellonia Białystok | - | Górnik Łęczna | 1:2 | ||||
| 19. Round | 18/12/2021 | Raków Częstochowa | - | Jagiellonia Białystok | 5:0 | ||||
| 20. Round | 04/02/2022 | Bruk-Bet Termalica Nieciecza | - | Jagiellonia Białystok | 2:1 | ||||
| 21. Round | 14/02/2022 | Górnik Zabrze | - | Jagiellonia Białystok | 1:2 |  |
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| 22. Round | 19/02/2022 | Jagiellonia Białystok | - | KS Cracovia | 0:0 | ||||
| 23. Round | 27/02/2022 | Jagiellonia Białystok | - | Warta Poznań | 1:1 | ||||
| 25. Round | 13/03/2022 | Jagiellonia Białystok | - | Wisła Płock | 0:1 | ||||
| 27. Round | 03/04/2022 | Jagiellonia Białystok | - | Zagłębie Lubin | 2:1 | ||||
| 28. Round | 11/04/2022 | Radomiak Radom | - | Jagiellonia Białystok | 2:2 | ||||
| 29. Round | 16/04/2022 | Jagiellonia Białystok | - | Pogoń Szczecin | 1:2 | ||||
| 30. Round | 23/04/2022 | Piast Gliwice | - | Jagiellonia Białystok | 2:1 | ||||
| 31. Round | 30/04/2022 | Jagiellonia Białystok | - | Śląsk Wrocław | 1:1 |
Poland