| 1. Round | 16/01/2022 | Santa Lucía | - | CSD Municipal | 0:2 | ||||
| 2. Round | 22/01/2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 11. Round | 05/03/2022 | CSD Municipal | - | Achuapa | 0:1 | ||||
| 12. Round | 12/03/2022 | CSD Municipal | - | Santa Lucía | 2:1 |  |
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| 13. Round | 20/03/2022 | Deportivo Guastatoya | - | CSD Municipal | 1:2 |  |
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| 15. Round | 04/04/2022 | Comunicaciones | - | CSD Municipal | 2:0 | ||||
| 14. Round | 06/04/2022 | CSD Municipal | - | Sololá FC | 4:0 | ||||
| 16. Round | 09/04/2022 | CSD Municipal | - | Deportivo Malacateco | 2:0 | ||||
| 19. Round | 13/04/2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 17. Round | 17/04/2022 | Xelaju MC | - | CSD Municipal | 0:1 | ||||
| 18. Round | 20/04/2022 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 20. Round | 30/04/2022 | CSD Municipal | - | Iztapa | 3:1 | ||||
| 21. Round | 04/05/2022 | CSD Municipal | - | Antigua GFC | 0:1 | |
Guatemala