| 2. Round | 12/08/2021 | Victoria | - | Motagua | 0:1 | ||||
| 3. Round | 15/08/2021 | Victoria | - | Real Sociedad | 0:2 | ||||
| 5. Round | 26/08/2021 | Vida | - | Victoria | 2:0 | ||||
| 8. Round | 12/09/2021 | Victoria | - | Marathón | 1:0 | ||||
| 11. Round | 23/09/2021 | Victoria | - | Honduras Progreso | 1:2 |  |
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| 13. Round | 10/10/2021 | Victoria | - | Real España | 0:2 | ||||
| 14. Round | 17/10/2021 | Real Sociedad | - | Victoria | 2:1 | ||||
| 1. Round | 21/10/2021 | Real España | - | Victoria | 1:1 | |
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| 15. Round | 24/10/2021 | Victoria | - | Vida | 1:2 |
Honduras