| 1. Round | 22/08/2020 | EA Guingamp | - | Chamois Niortais | 0:1 | ||||
| 2. Round | 29/08/2020 | AS Nancy Lorraine | - | EA Guingamp | 2:2 | ||||
| 3. Round | 12/09/2020 | EA Guingamp | - | Havre AC | 1:3 | ||||
| 4. Round | 19/09/2020 | Pau FC | - | EA Guingamp | 0:1 | ||||
| 5. Round | 26/09/2020 | EA Guingamp | - | Grenoble Foot 38 | 1:0 | ||||
| 6. Round | 03/10/2020 | USL Dunkerque | - | EA Guingamp | 1:0 |  |
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| 7. Round | 19/10/2020 | EA Guingamp | - | AJ Auxerre | 2:0 | ||||
| 8. Round | 24/10/2020 | SM Caen | - | EA Guingamp | 1:0 | ||||
| 9. Round | 31/10/2020 | EA Guingamp | - | FC Sochaux | 0:0 | ||||
| 10. Round | 07/11/2020 | Clermont Foot 63 | - | EA Guingamp | 0:0 | ||||
| 11. Round | 23/11/2020 | EA Guingamp | - | AC Ajaccio | 2:2 | ||||
| 12. Round | 28/11/2020 | Rodez AF | - | EA Guingamp | 1:1 | ||||
| 13. Round | 01/12/2020 | EA Guingamp | - | ESTAC Troyes | 1:2 | ||||
| 14. Round | 05/12/2020 | Toulouse FC | - | EA Guingamp | 2:2 | ||||
| 15. Round | 12/12/2020 | EA Guingamp | - | Valenciennes FC | 1:1 | ||||
| 17. Round | 22/12/2020 | Paris FC | - | EA Guingamp | 3:2 |
Portugal