| 3. Round | 30/09/2000 | Panathinaikos | - | Aris Saloniki | 2:2 | ||||
| 5. Round | 04/11/2000 | Panathinaikos | - | Paniliakos Pyrgos | 2:0 |  |
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| 7. Round | 17/11/2000 | PAOK Saloniki | - | Panathinaikos | 2:2 | |
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| 8. Round | 24/11/2000 | Panathinaikos | - | Skoda Xanthi | 3:0 | ||||
| 10. Round | 09/12/2000 | Panathinaikos | - | Athinaikos | 1:0 | ||||
| 11. Round | 16/12/2000 | Ethnikos Asteras | - | Panathinaikos | 0:3 | ||||
| 12. Round | 02/01/2001 | Panathinaikos | - | Ionikos Nikea | 4:1 | ||||
| 13. Round | 06/01/2001 | AEK Athen | - | Panathinaikos | 1:1 | ||||
| 14. Round | 13/01/2001 | Panachaiki GE | - | Panathinaikos | 1:2 | ||||
| 15. Round | 20/01/2001 | Panathinaikos | - | PS Kalamata | 1:0 | ||||
| 18. Round | 09/02/2001 | Aris Saloniki | - | Panathinaikos | 1:0 | ||||
| 20. Round | 23/02/2001 | Paniliakos Pyrgos | - | Panathinaikos | 0:3 | |
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| 22. Round | 09/03/2001 | Panathinaikos | - | PAOK Saloniki | 5:2 | ||||
| 23. Round | 16/03/2001 | Skoda Xanthi | - | Panathinaikos | 0:2 | ||||
| 28. Round | 06/05/2001 | Panathinaikos | - | AEK Athen | 0:1 | |
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| 29. Round | 19/05/2001 | Panathinaikos | - | Panachaiki GE | 4:0 | ||||
| 30. Round | 26/05/2001 | PS Kalamata | - | Panathinaikos | 2:4 |
Peru