| 2. Round | 16/08/2020 | RSC Anderlecht | - | Sint-Truidense VV | 3:1 |  |
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| 3. Round | 23/08/2020 | RSC Anderlecht | - | Royal Excel Mouscron | 1:1 | ||||
| 4. Round | 28/08/2020 | KV Oostende | - | RSC Anderlecht | 2:2 | |
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| 5. Round | 13/09/2020 | RSC Anderlecht | - | Cercle Brugge | 2:0 | ||||
| 6. Round | 19/09/2020 | Waasland-Beveren | - | RSC Anderlecht | 2:4 | ||||
| 7. Round | 27/09/2020 | RSC Anderlecht | - | KAS Eupen | 1:1 | ||||
| 8. Round | 04/10/2020 | Club Brugge KV | - | RSC Anderlecht | 3:0 | ||||
| 9. Round | 18/10/2020 | RSC Anderlecht | - | Oud-Heverlee Leuven | 2:2 | |
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| 10. Round | 23/10/2020 | KV Kortrijk | - | RSC Anderlecht | 1:3 | |
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| 11. Round | 01/11/2020 | RSC Anderlecht | - | Royal Antwerp FC | 1:0 | ||||
| 12. Round | 08/11/2020 | KAA Gent | - | RSC Anderlecht | 1:1 |  |
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| 13. Round | 22/11/2020 | K Beerschot VA | - | RSC Anderlecht | 2:1 | ||||
| 17. Round | 18/12/2020 | Sporting Charleroi | - | RSC Anderlecht | 1:0 | ||||
| 19. Round | 27/12/2020 | RSC Anderlecht | - | K Beerschot VA | 2:0 |
South Africa
