| Group B | 15/09/2016 | APOEL Nikosia | - | FK Astana | 2:1 | ||||
| Group B | 29/09/2016 | Olympiakos Piraeus | - | APOEL Nikosia | 0:1 |  |
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| Group B | 20/10/2016 | BSC Young Boys | - | APOEL Nikosia | 3:1 | |
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| Group B | 03/11/2016 | APOEL Nikosia | - | BSC Young Boys | 1:0 | |
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| Group B | 24/11/2016 | FK Astana | - | APOEL Nikosia | 2:1 | ||||
| Group B | 08/12/2016 | APOEL Nikosia | - | Olympiakos Piraeus | 2:0 | ||||
| Round of 32 | 16/02/2017 | Athletic Club | - | APOEL Nikosia | 3:2 | ||||
| Round of 32 | 23/02/2017 | APOEL Nikosia | - | Athletic Club | 2:0 | |
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| Round of 16 | 16/03/2017 | RSC Anderlecht | - | APOEL Nikosia | 1:0 |
Cyprus