| 2. Round | 22/08/2021 | Arsenal FC | - | Chelsea FC | 0:2 | ||||
| 3. Round | 28/08/2021 | Manchester City | - | Arsenal FC | 5:0 | ||||
| 4. Round | 11/09/2021 | Arsenal FC | - | Norwich City | 1:0 |  |
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| 5. Round | 18/09/2021 | Burnley FC | - | Arsenal FC | 0:1 | ||||
| 6. Round | 26/09/2021 | Arsenal FC | - | Tottenham Hotspur | 3:1 | |
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| 7. Round | 02/10/2021 | Brighton & Hove Albion | - | Arsenal FC | 0:0 | ||||
| 8. Round | 18/10/2021 | Arsenal FC | - | Crystal Palace | 2:2 | |
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| 9. Round | 22/10/2021 | Arsenal FC | - | Aston Villa | 3:1 | |
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| 10. Round | 30/10/2021 | Leicester City | - | Arsenal FC | 0:2 | ||||
| 11. Round | 07/11/2021 | Arsenal FC | - | Watford FC | 1:0 | |
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| 12. Round | 20/11/2021 | Liverpool FC | - | Arsenal FC | 4:0 | ||||
| 13. Round | 27/11/2021 | Arsenal FC | - | Newcastle United | 2:0 | |
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| 14. Round | 02/12/2021 | Manchester United | - | Arsenal FC | 3:2 | ||||
| 15. Round | 06/12/2021 | Everton FC | - | Arsenal FC | 2:1 |
France
