| 23. Round | 06/02/2022 | FC Barcelona | - | Atlético Madrid | 4:2 | ||||
| 24. Round | 13/02/2022 | Espanyol Barcelona | - | FC Barcelona | 2:2 | ||||
| 25. Round | 20/02/2022 | Valencia CF | - | FC Barcelona | 1:4 |  |
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| 26. Round | 27/02/2022 | FC Barcelona | - | Athletic Club | 4:0 | |
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| 27. Round | 06/03/2022 | Elche CF | - | FC Barcelona | 1:2 | ||||
| 28. Round | 13/03/2022 | FC Barcelona | - | CA Osasuna | 4:0 | |
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| 29. Round | 20/03/2022 | Real Madrid | - | FC Barcelona | 0:4 | |
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| 30. Round | 03/04/2022 | FC Barcelona | - | Sevilla FC | 1:0 | ||||
| 31. Round | 10/04/2022 | Levante UD | - | FC Barcelona | 2:3 | |
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| 32. Round | 18/04/2022 | FC Barcelona | - | Cádiz CF | 0:1 | ||||
| 33. Round | 21/04/2022 | Real Sociedad | - | FC Barcelona | 0:1 | |
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| 21. Round | 24/04/2022 | FC Barcelona | - | Rayo Vallecano | 0:1 | ||||
| 34. Round | 01/05/2022 | FC Barcelona | - | RCD Mallorca | 2:1 | ||||
| 35. Round | 07/05/2022 | Real Betis | - | FC Barcelona | 1:2 | ||||
| 36. Round | 10/05/2022 | FC Barcelona | - | RC Celta | 3:1 | |
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| 37. Round | 15/05/2022 | Getafe CF | - | FC Barcelona | 0:0 | ||||
| 38. Round | 22/05/2022 | FC Barcelona | - | Villarreal CF | 0:2 |
France
