| 22. Round | 18/02/2000 | NEC Nijmegen | - | RKC Waalwijk | 3:1 | ||||
| 23. Round | 26/02/2000 | Sparta Rotterdam | - | NEC Nijmegen | 1:0 | ||||
| 24. Round | 04/03/2000 | NEC Nijmegen | - | FC Utrecht | 0:1 | ||||
| 25. Round | 09/03/2000 | NEC Nijmegen | - | Fortuna Sittard | 1:2 | ||||
| 26. Round | 16/03/2000 | NEC Nijmegen | - | Willem II | 2:1 | ||||
| 27. Round | 25/03/2000 | AFC Ajax | - | NEC Nijmegen | 5:2 | ||||
| 29. Round | 06/04/2000 | NEC Nijmegen | - | Roda JC Kerkrade | 0:0 | ||||
| 30. Round | 15/04/2000 | FC Den Bosch | - | NEC Nijmegen | 1:1 | ||||
| 31. Round | 22/04/2000 | NEC Nijmegen | - | Vitesse | 1:0 | ||||
| 32. Round | 29/04/2000 | MVV | - | NEC Nijmegen | 2:0 | ||||
| 33. Round | 06/05/2000 | NEC Nijmegen | - | Feyenoord | 0:2 | ||||
| 34. Round | 13/05/2000 | PSV Eindhoven | - | NEC Nijmegen | 2:0 |  |
Belgium