| 1. Round | 30/07/2021 | GKS Tychy '71 | - | ŁKS Łódź | 1:1 | ||||
| 2. Round | 08/08/2021 | ŁKS Łódź | - | Skra Częstochowa | 3:2 | ||||
| 3. Round | 13/08/2021 | Puszcza Niepołomice | - | ŁKS Łódź | 0:2 | ||||
| 4. Round | 18/08/2021 | ŁKS Łódź | - | GKS Jastrzębie | 2:2 |  |
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| 5. Round | 21/08/2021 | Korona Kielce | - | ŁKS Łódź | 1:0 | ||||
| 6. Round | 27/08/2021 | OKS Stomil Olsztyn | - | ŁKS Łódź | 0:3 |  |
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| 7. Round | 05/09/2021 | ŁKS Łódź | - | Resovia Rzeszów | 0:3 | ||||
| 8. Round | 11/09/2021 | Miedź Legnica | - | ŁKS Łódź | 0:2 | |
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| 9. Round | 18/09/2021 | ŁKS Łódź | - | Podbeskidzie Bielsko-Biała | 1:2 | |
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| 21. Round | 26/02/2022 | GKS Jastrzębie | - | ŁKS Łódź | 1:1 | |
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| 22. Round | 05/03/2022 | ŁKS Łódź | - | Korona Kielce | 0:0 | ||||
| 24. Round | 20/03/2022 | Resovia Rzeszów | - | ŁKS Łódź | 1:2 | ||||
| 25. Round | 25/03/2022 | ŁKS Łódź | - | Miedź Legnica | 0:1 | ||||
| 31. Round | 03/05/2022 | ŁKS Łódź | - | Widzew Łódź | 0:1 | ||||
| 32. Round | 08/05/2022 | KS Polkowice | - | ŁKS Łódź | 0:2 | ||||
| 33. Round | 15/05/2022 | ŁKS Łódź | - | Odra Opole | 0:4 | ||||
| 34. Round | 22/05/2022 | GKS Katowice | - | ŁKS Łódź | 2:0 |
Poland