| 20. Round | 30/01/2010 | FC Schalke 04 | - | 1899 Hoffenheim | 2:0 | ||||
| 22. Round | 13/02/2010 | VfL Bochum | - | 1899 Hoffenheim | 2:1 | ||||
| 23. Round | 19/02/2010 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 2:2 | ||||
| 25. Round | 07/03/2010 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 0:1 | ||||
| 26. Round | 14/03/2010 | 1899 Hoffenheim | - | Werder Bremen | 0:1 | ||||
| 27. Round | 20/03/2010 | 1. FC Nürnberg | - | 1899 Hoffenheim | 0:0 | ||||
| 28. Round | 28/03/2010 | 1899 Hoffenheim | - | SC Freiburg | 1:1 | ||||
| 29. Round | 04/04/2010 | VfL Wolfsburg | - | 1899 Hoffenheim | 4:0 | ||||
| 30. Round | 10/04/2010 | 1899 Hoffenheim | - | 1. FC Köln | 0:2 | ||||
| 31. Round | 18/04/2010 | Borussia Dortmund | - | 1899 Hoffenheim | 1:1 | ||||
| 33. Round | 01/05/2010 | Eintracht Frankfurt | - | 1899 Hoffenheim | 1:2 |  |
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| 34. Round | 08/05/2010 | 1899 Hoffenheim | - | VfB Stuttgart | 1:1 |
Ghana