| 1. Round | 10/02/2008 | River Plate | - | Gimnasia de Jujuy | 2:0 | ||||
| 2. Round | 17/02/2008 | Newell's Old Boys | - | River Plate | 0:0 | ||||
| 3. Round | 24/02/2008 | River Plate | - | San Lorenzo | 2:0 |  |
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| 5. Round | 09/03/2008 | Estudiantes | - | River Plate | 0:0 | ||||
| 6. Round | 16/03/2008 | River Plate | - | Racing Club | 0:0 | ||||
| 4. Round | 19/03/2008 | River Plate | - | San Martín de San Juan | 3:2 | ||||
| 7. Round | 23/03/2008 | Vélez Sarsfield | - | River Plate | 0:2 | |
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| 9. Round | 06/04/2008 | Lanús | - | River Plate | 0:1 | ||||
| 10. Round | 13/04/2008 | River Plate | - | Tigre | 1:0 | |
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| 11. Round | 20/04/2008 | Rosario Central | - | River Plate | 2:1 | ||||
| 12. Round | 27/04/2008 | River Plate | - | Argentinos Juniors | 4:2 | |
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| 13. Round | 04/05/2008 | Boca Juniors | - | River Plate | 1:0 |  |
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| 15. Round | 18/05/2008 | Independiente | - | River Plate | 0:0 | ||||
| 16. Round | 24/05/2008 | River Plate | - | Huracán | 1:0 | ||||
| 18. Round | 08/06/2008 | River Plate | - | Olimpo de Bahía Blanca | 2:1 | ||||
| 19. Round | 22/06/2008 | Banfield | - | River Plate | 2:3 | |
Colombia
Venezuela 
