| 2. Round | 24/07/2021 | Crvena Zvezda | - | Mladost Lučani | 1:0 | ||||
| 3. Round | 31/07/2021 | Spartak Subotica | - | Crvena Zvezda | 1:3 |  |
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| 6. Round | 21/08/2021 | Crvena Zvezda | - | TSC Bačka Topola | 3:1 | ||||
| 8. Round | 11/09/2021 | Crvena Zvezda | - | Proleter Novi Sad | 3:0 | ||||
| 13. Round | 16/10/2021 | FK Kolubara | - | Crvena Zvezda | 1:7 | ||||
| 14. Round | 24/10/2021 | Crvena Zvezda | - | Radnički Niš | 1:0 | ||||
| 16. Round | 07/11/2021 | Vojvodina | - | Crvena Zvezda | 1:2 | ||||
| 10. Round | 01/12/2021 | Crvena Zvezda | - | FK Voždovac | 1:0 | ||||
| 21. Round | 16/12/2021 | TSC Bačka Topola | - | Crvena Zvezda | 2:3 | |
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| 23. Round | 20/02/2022 | Proleter Novi Sad | - | Crvena Zvezda | 1:2 | ||||
| 24. Round | 27/02/2022 | Crvena Zvezda | - | Partizan | 2:0 | ||||
| 25. Round | 03/03/2022 | FK Voždovac | - | Crvena Zvezda | 0:3 | ||||
| 26. Round | 06/03/2022 | Crvena Zvezda | - | FK Novi Pazar | 5:0 | ||||
| 27. Round | 14/03/2022 | FK Metalac | - | Crvena Zvezda | 1:2 | ||||
| 30. Round | 10/04/2022 | Crvena Zvezda | - | FK Radnički 1923 | 4:1 |
Serbia