| 1. Round | 24/02/2022 | Academia Puerto Cabello | - | Portuguesa FC | 1:1 | ||||
| 2. Round | 06/03/2022 | Deportivo La Guaira | - | Academia Puerto Cabello | 2:1 | ||||
| 4. Round | 18/03/2022 | Deportivo Táchira | - | Academia Puerto Cabello | 1:1 | ||||
| 5. Round | 25/03/2022 | Hermanos Colmenarez | - | Academia Puerto Cabello | 4:1 | ||||
| 6. Round | 01/04/2022 | Academia Puerto Cabello | - | Caracas FC | 0:0 | ||||
| 8. Round | 15/04/2022 | Academia Puerto Cabello | - | Monagas | 0:2 | ||||
| 10. Round | 30/04/2022 | Academia Puerto Cabello | - | Estudiantes de Mérida | 1:0 | ||||
| 13. Round | 20/05/2022 | Zamora FC | - | Academia Puerto Cabello | 1:0 |
Panama