| 1. Round | 07/08/2022 | FC Groningen | - | FC Volendam | 2:2 | ||||
| 2. Round | 14/08/2022 | AFC Ajax | - | FC Groningen | 6:1 | ||||
| 3. Round | 21/08/2022 | FC Groningen | - | Go Ahead Eagles | 1:0 | ||||
| 8. Round | 01/10/2022 | FC Groningen | - | AZ Alkmaar | 1:4 | ||||
| 9. Round | 07/10/2022 | FC Groningen | - | RKC Waalwijk | 2:3 | ||||
| 10. Round | 16/10/2022 | FC Twente | - | FC Groningen | 3:0 | ||||
| 11. Round | 23/10/2022 | FC Groningen | - | PSV Eindhoven | 4:2 | ||||
| 12. Round | 30/10/2022 | FC Emmen | - | FC Groningen | 0:0 | ||||
| 13. Round | 06/11/2022 | FC Utrecht | - | FC Groningen | 2:1 | ||||
| 14. Round | 13/11/2022 | FC Groningen | - | Fortuna Sittard | 2:3 | ||||
| 15. Round | 08/01/2023 | SBV Excelsior | - | FC Groningen | 1:0 | ||||
| 16. Round | 15/01/2023 | FC Groningen | - | Feyenoord | 0:3 | ||||
| 17. Round | 22/01/2023 | sc Heerenveen | - | FC Groningen | 3:1 | ||||
| 18. Round | 26/01/2023 | FC Groningen | - | SC Cambuur | 0:1 | ||||
| 19. Round | 29/01/2023 | FC Volendam | - | FC Groningen | 3:2 | ||||
| 21. Round | 11/02/2023 | PSV Eindhoven | - | FC Groningen | 6:0 | ||||
| 22. Round | 18/02/2023 | FC Groningen | - | FC Emmen | 1:1 |  |
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| 23. Round | 25/02/2023 | FC Groningen | - | SBV Excelsior | 3:0 | ||||
| 27. Round | 02/04/2023 | Fortuna Sittard | - | FC Groningen | 3:1 |
Netherlands