| 2. Round | 16/01/2022 | Deportivo Saprissa | - | AD San Carlos | 1:2 | ||||
| 4. Round | 04/02/2022 | Guadalupe | - | AD San Carlos | 3:1 |  |
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| 7. Round | 19/02/2022 | Municipal Grecia | - | AD San Carlos | 0:1 | ||||
| 9. Round | 02/03/2022 | CS Cartaginés | - | AD San Carlos | 1:1 | ||||
| 1. Round | 13/03/2022 | AD San Carlos | - | Santos de Guápiles | 1:0 | ||||
| 15. Round | 20/04/2022 | AD San Carlos | - | Guadalupe | 2:1 |  |
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| 16. Round | 24/04/2022 | CS Herediano | - | AD San Carlos | 1:1 | ||||
| 19. Round | 04/05/2022 | Jicaral | - | AD San Carlos | 2:1 | ||||
| 22. Round | 15/05/2022 | AD San Carlos | - | Sporting FC | 2:1 |
Costa Rica
Nicaragua