| 2. Round | 05/09/2021 | Villarreal CF B | - | UE Cornellà | 3:0 | ||||
| 3. Round | 12/09/2021 | Atlético Baleares | - | Villarreal CF B | 0:0 | ||||
| 5. Round | 26/09/2021 | Villarreal CF B | - | UE Costa Brava | 2:0 | ||||
| 6. Round | 01/10/2021 | CE Sabadell | - | Villarreal CF B | 0:1 | ||||
| 7. Round | 10/10/2021 | Villarreal CF B | - | Sevilla Atlético | 5:1 | ||||
| 8. Round | 16/10/2021 | Real Betis B | - | Villarreal CF B | 1:2 | ||||
| 11. Round | 07/11/2021 | Villarreal CF B | - | CD Alcoyano | 0:1 | ||||
| 12. Round | 13/11/2021 | Linares Deportivo | - | Villarreal CF B | 2:1 | ||||
| 14. Round | 27/11/2021 | RB Linense | - | Villarreal CF B | 1:2 | ||||
| 13. Round | 18/01/2022 | Villarreal CF B | - | CD Castellón | 3:2 | ||||
| 19. Round | 23/01/2022 | Villarreal CF B | - | Atlético Sanluqueño CF | 4:1 | ||||
| 20. Round | 26/01/2022 | Sevilla Atlético | - | Villarreal CF B | 2:1 |  |
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| 21. Round | 29/01/2022 | Villarreal CF B | - | San Fernando CD | 0:3 | ||||
| 23. Round | 13/02/2022 | FC Andorra | - | Villarreal CF B | 0:1 | ||||
| 24. Round | 19/02/2022 | Villarreal CF B | - | Real Betis B | 3:0 | ||||
| 25. Round | 26/02/2022 | Albacete | - | Villarreal CF B | 1:0 | ||||
| 32. Round | 16/04/2022 | Villarreal CF B | - | Linares Deportivo | 5:0 |
Spain