| 1. Round | 22/01/2022 | CD Walter Ferretti | - | Real Madriz | 3:0 | ||||
| 2. Round | 06/02/2022 | Real Madriz | - | Real Estelí FC | 0:0 |  |
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| 3. Round | 09/02/2022 | Real Madriz | - | Juventus Managua | 0:3 | ||||
| 4. Round | 13/02/2022 | Real Madriz | - | UNAN Managua | 0:1 | ||||
| 5. Round | 21/02/2022 | Club Deportivo Ocotal | - | Real Madriz | 2:0 | ||||
| 6. Round | 27/02/2022 | ART Municipal Jalapa | - | Real Madriz | 0:1 | |
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| 7. Round | 03/03/2022 | Diriangén FC | - | Real Madriz | 3:0 | ||||
| 8. Round | 07/03/2022 | Real Madriz | - | Managua FC | 1:0 | ||||
| 9. Round | 09/03/2022 | H&H Export Sébaco | - | Real Madriz | 1:1 | |
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| 11. Round | 20/03/2022 | Real Estelí FC | - | Real Madriz | 4:0 | ||||
| 12. Round | 03/04/2022 | Juventus Managua | - | Real Madriz | 1:1 | |
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| 13. Round | 07/04/2022 | UNAN Managua | - | Real Madriz | 3:1 | ||||
| 14. Round | 10/04/2022 | Real Madriz | - | Club Deportivo Ocotal | 0:1 | |
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| 15. Round | 14/04/2022 | Real Madriz | - | Diriangén FC | 2:2 | ||||
| 16. Round | 25/04/2022 | Real Madriz | - | ART Municipal Jalapa | 3:0 dec. | |
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| 18. Round | 01/05/2022 | Real Madriz | - | H&H Export Sébaco | 0:0 |
Nicaragua