| 6. Round | 22/02/2025 | San Francisco FC | - | Tauro FC | 1:1 | ||||
| 7. Round | 26/02/2025 | San Francisco FC | - | Plaza Amador | 0:1 | ||||
| 10. Round | 23/03/2025 | Árabe Unido | - | San Francisco FC | 1:3 | ||||
| 11. Round | 29/03/2025 | San Francisco FC | - | Alianza | 1:2 | ||||
| 12. Round | 05/04/2025 | San Francisco FC | - | Veraguas United | 4:0 | ||||
| 13. Round | 12/04/2025 | San Francisco FC | - | Herrera FC | 1:1 |  |
|||
| 16. Round | 10/05/2025 | San Francisco FC | - | UD Universitario | 3:0 |
Panama