| 13. Round | 27/09/2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 3:0 | ||||
| 14. Round | 03/10/2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 |  |
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| 15. Round | 12/10/2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:1 | ||||
| 16. Round | 17/10/2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | |
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| 17. Round | 23/10/2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 3:1 | ||||
| 18. Round | 28/10/2021 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:0 | ||||
| 19. Round | 30/10/2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 3:2 | |
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| 21. Round | 23/11/2021 | Municipal Pérez Zeledón | - | Sporting FC | 1:0 | ||||
| 22. Round | 28/11/2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:0 |
Costa Rica