| 1. Round | 21/07/2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 2:0 | ||||
| 2. Round | 25/07/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 2:1 | ||||
| 3. Round | 31/07/2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 2:3 | ||||
| 5. Round | 12/08/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 |  |
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| 6. Round | 16/08/2022 | Municipal Pérez Zeledón | - | Puntarenas FC | 1:2 | |
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| 8. Round | 28/08/2022 | Municipal Pérez Zeledón | - | AD San Carlos | 0:2 | ||||
| 15. Round | 30/09/2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 1:1 | |
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| 16. Round | 03/10/2022 | Municipal Pérez Zeledón | - | Sporting FC | 1:0 |
Panama