| 8. Round | 09/02/2022 | ENPPI | - | Misr lel-Maqasah SC | 0:0 | ||||
| 9. Round | 14/02/2022 | Misr lel-Maqasah SC | - | Tala'ea El Gaish SC | 0:0 | ||||
| 10. Round | 22/02/2022 | Al Ahly SC | - | Misr lel-Maqasah SC | 4:0 | ||||
| 11. Round | 01/03/2022 | Misr lel-Maqasah SC | - | Ismaily | 2:2 |  |
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| 12. Round | 07/03/2022 | National Bank SC | - | Misr lel-Maqasah SC | 1:0 | ||||
| 13. Round | 09/04/2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Round | 14/04/2022 | Al Mokawloon | - | Misr lel-Maqasah SC | 1:1 | ||||
| 18. Round | 11/05/2022 | Misr lel-Maqasah SC | - | Pyramids FC | 0:2 | ||||
| 20. Round | 22/05/2022 | Ceramica Cleopatra | - | Misr lel-Maqasah SC | 4:1 | ||||
| 21. Round | 27/05/2022 | Misr lel-Maqasah SC | - | Pharco FC | 0:0 | ||||
| 23. Round | 26/06/2022 | Misr lel-Maqasah SC | - | Al Masry Club | 0:2 |
Nigeria