| 8. Round | 12/09/2021 | Gaz Metan Mediaş | - | FC Voluntari | 1:2 | ||||
| 12. Round | 15/10/2021 | Gaz Metan Mediaş | - | Dinamo Bucureşti | 2:1 | ||||
| 13. Round | 22/10/2021 | FC Universitatea Craiova | - | Gaz Metan Mediaş | 2:0 | ||||
| 14. Round | 31/10/2021 | Gaz Metan Mediaş | - | Academica Clinceni | 1:1 | ||||
| 16. Round | 22/11/2021 | CS Mioveni | - | Gaz Metan Mediaş | 1:0 | ||||
| 17. Round | 29/11/2021 | Gaz Metan Mediaş | - | Farul Constanța | 1:1 | ||||
| 18. Round | 06/12/2021 | Argeș Pitești | - | Gaz Metan Mediaş | 1:2 |  |
|||
| 19. Round | 11/12/2021 | Gaz Metan Mediaş | - | FCSB | 0:1 |  |
|||
| 20. Round | 15/12/2021 | FC Botoşani | - | Gaz Metan Mediaş | 2:1 | |
|||
| 21. Round | 18/12/2021 | Gaz Metan Mediaş | - | CS Universitatea Craiova | 1:1 | ||||
| 25. Round | 08/02/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 | ||||
| 27. Round | 18/02/2022 | Dinamo Bucureşti | - | Gaz Metan Mediaş | 4:0 | ||||
| 28. Round | 26/02/2022 | Gaz Metan Mediaş | - | FC Universitatea Craiova | 0:3 | ||||
| 29. Round | 02/03/2022 | Academica Clinceni | - | Gaz Metan Mediaş | 2:0 | ||||
| 30. Round | 06/03/2022 | Gaz Metan Mediaş | - | Chindia Târgoviște | 0:4 |
Romania