| 7. Round | 24/04/2021 | Sligo Rovers | - | Derry City | 0:1 | ||||
| 12. Round | 21/05/2021 | Sligo Rovers | - | Longford Town | 2:0 | ||||
| 16. Round | 18/06/2021 | St Patrick's Athletic | - | Sligo Rovers | 2:0 | ||||
| 17. Round | 21/06/2021 | Derry City | - | Sligo Rovers | 1:1 | ||||
| 18. Round | 26/06/2021 | Sligo Rovers | - | Bohemian FC | 4:0 | ||||
| 21. Round | 18/07/2021 | Waterford FC | - | Sligo Rovers | 1:0 | ||||
| 24. Round | 15/08/2021 | Bohemian FC | - | Sligo Rovers | 1:0 |  |
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| 28. Round | 24/09/2021 | Dundalk FC | - | Sligo Rovers | 4:1 | ||||
| 31. Round | 15/10/2021 | Shamrock Rovers | - | Sligo Rovers | 2:0 | ||||
| 35. Round | 12/11/2021 | Derry City | - | Sligo Rovers | 2:0 |
England