| 1. Round | 14/01/2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 2:0 | ||||
| 2. Round | 17/01/2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 2:0 | ||||
| 3. Round | 22/01/2021 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | ||||
| 4. Round | 24/01/2021 | Municipal Grecia | - | Municipal Pérez Zeledón | 0:0 |  |
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| 5. Round | 01/02/2021 | Municipal Pérez Zeledón | - | Jicaral | 1:2 | ||||
| 6. Round | 12/02/2021 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 1:1 | ||||
| 8. Round | 16/02/2021 | Municipal Pérez Zeledón | - | Guadalupe | 1:3 | ||||
| 12. Round | 06/03/2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:5 | ||||
| 13. Round | 14/03/2021 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 14. Round | 20/03/2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 0:0 | ||||
| 17. Round | 11/04/2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 1:1 | ||||
| 18. Round | 18/04/2021 | Municipal Pérez Zeledón | - | Limón FC | 3:2 | ||||
| 22. Round | 13/05/2021 | Municipal Pérez Zeledón | - | Sporting FC | 3:1 | |
Costa Rica