1. Round | 08/08/2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
2. Round | 11/08/2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
6. Round | 31/08/2021 | Motagua | - | Lobos UPNFM | 0:0 | ||||
7. Round | 04/09/2021 | Lobos UPNFM | - | Victoria | 3:0 | ||||
9. Round | 15/09/2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
10. Round | 19/09/2021 | Lobos UPNFM | - | Motagua | 2:2 | ||||
11. Round | 26/09/2021 | Platense | - | Lobos UPNFM | 2:3 | ||||
12. Round | 03/10/2021 | Lobos UPNFM | - | Marathón | 1:1 | ||||
13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
14. Round | 17/10/2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
16. Round | 27/10/2021 | Real Sociedad | - | Lobos UPNFM | 0:3 |