| 2. Round | 06/08/2022 | FC Sfîntul Gheorghe | - | FC Sheriff | 1:3 | ||||
| 6. Round | 03/09/2022 | Dacia Buiucani | - | FC Sheriff | 0:2 | ||||
| 7. Round | 11/09/2022 | FC Sheriff | - | FC Milsami | 2:0 | ||||
| 8. Round | 18/09/2022 | FC Sheriff | - | FC Zimbru | 0:0 | ||||
| 10. Round | 09/10/2022 | Dinamo-Auto | - | FC Sheriff | 0:1 | ||||
| 11. Round | 16/10/2022 | FC Sheriff | - | FC Bălţi | 2:1 | ||||
| 12. Round | 23/10/2022 | CS Petrocub | - | FC Sheriff | 1:0 |
Brazil