| 17. Round | 06/02/2022 | Sirens FC | - | Valletta FC | 2:1 | ||||
| 18. Round | 13/02/2022 | Birkirkara FC | - | Sirens FC | 1:1 |  |
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| 19. Round | 19/02/2022 | Sirens FC | - | Hamrun Spartans | 1:1 | ||||
| 20. Round | 27/02/2022 | Balzan FC | - | Sirens FC | 2:1 | ||||
| 21. Round | 06/03/2022 | Sirens FC | - | Floriana FC | 0:3 | ||||
| 22. Round | 12/03/2022 | Gżira United | - | Sirens FC | 2:1 |
Brazil