| 1. Round | 26/02/2022 | Mineros de Guayana | - | Monagas | 1:3 | ||||
| 2. Round | 06/03/2022 | Portuguesa FC | - | Mineros de Guayana | 0:2 |  |
 |
||
| 3. Round | 10/03/2022 | Mineros de Guayana | - | Deportivo Lara | 1:0 | ||||
| 4. Round | 17/03/2022 | Carabobo FC | - | Mineros de Guayana | 3:1 | ||||
| 5. Round | 26/03/2022 | Mineros de Guayana | - | Aragua FC | 0:3 | ||||
| 6. Round | 01/04/2022 | Zamora FC | - | Mineros de Guayana | 1:1 | ||||
| 7. Round | 10/04/2022 | Mineros de Guayana | - | Academia Puerto Cabello | 2:0 | ||||
| 9. Round | 24/04/2022 | Mineros de Guayana | - | Zulia FC | 0:3 | ||||
| 10. Round | 01/05/2022 | Universidad Central | - | Mineros de Guayana | 0:2 | |
|||
| 13. Round | 22/05/2022 | Mineros de Guayana | - | Deportivo Táchira | 1:2 | ||||
| 14. Round | 28/05/2022 | Estudiantes de Mérida | - | Mineros de Guayana | 2:0 |
Venezuela