| 6. Round | 18/09/2021 | The New Saints | - | Barry Town United | 3:1 |  |
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| 7. Round | 02/10/2021 | Barry Town United | - | Newtown AFC | 0:3 | ||||
| 8. Round | 09/10/2021 | Flint Town United | - | Barry Town United | 3:2 |  |
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| 9. Round | 12/10/2021 | Barry Town United | - | Cardiff Metropolitan | 0:1 | ||||
| 10. Round | 23/10/2021 | Bala Town | - | Barry Town United | 3:3 | ||||
| 11. Round | 30/10/2021 | Caernarfon Town | - | Barry Town United | 1:2 | |
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| 12. Round | 06/11/2021 | Barry Town United | - | Aberystwyth Town | 1:1 | |
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| 13. Round | 09/11/2021 | Haverfordwest County | - | Barry Town United | 1:1 | ||||
| 16. Round | 11/12/2021 | Barry Town United | - | The New Saints | 1:2 | ||||
| 20. Round | 22/01/2022 | Barry Town United | - | Flint Town United | 0:1 | ||||
| 17. Round | 25/01/2022 | Cardiff Metropolitan | - | Barry Town United | 2:0 | ||||
| 19. Round | 11/02/2022 | Barry Town United | - | Penybont FC | 0:0 | |
Wales