| 1. Round | 13/07/2022 | Boyacá Chicó | - | Barranquilla FC | 1:0 | ||||
| 2. Round | 16/07/2022 | Barranquilla FC | - | Tigres FC | 3:0 |  |
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| 3. Round | 24/07/2022 | Cúcuta Deportivo | - | Barranquilla FC | 0:1 | ||||
| 4. Round | 30/07/2022 | Llaneros FC | - | Barranquilla FC | 1:1 | ||||
| 5. Round | 03/08/2022 | Barranquilla FC | - | Boca Juniors de Cali | 1:1 | ||||
| 6. Round | 09/08/2022 | Barranquilla FC | - | Leones FC | 3:1 | ||||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | ||||
| 9. Round | 31/08/2022 | Real Cartagena | - | Barranquilla FC | 2:2 | ||||
| 10. Round | 03/09/2022 | Barranquilla FC | - | Atlético Huila | 2:1 | ||||
| 11. Round | 07/09/2022 | Fortaleza FC | - | Barranquilla FC | 3:0 | ||||
| 12. Round | 14/09/2022 | Barranquilla FC | - | Real Santander | 2:1 | |
Colombia