| 1. Round | 08/08/2021 | Sporting San Miguelito | - | Alianza | 1:2 | ||||
| 2. Round | 15/08/2021 | Plaza Amador | - | Sporting San Miguelito | 0:0 | ||||
| 3. Round | 21/08/2021 | Sporting San Miguelito | - | Tauro FC | 1:0 |  |
 |
||
| 4. Round | 29/08/2021 | Sporting San Miguelito | - | Deportivo del Este | 1:1 | |
|
||
| 5. Round | 04/09/2021 | Árabe Unido | - | Sporting San Miguelito | 0:1 | ||||
| 6. Round | 11/09/2021 | Sporting San Miguelito | - | UD Universitario | 1:0 | |
|||
| 8. Round | 26/09/2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Round | 03/10/2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Round | 10/10/2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 13. Round | 31/10/2021 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Round | 07/11/2021 | Tauro FC | - | Sporting San Miguelito | 1:0 | ||||
| 15. Round | 13/11/2021 | Deportivo del Este | - | Sporting San Miguelito | 1:0 | |
|||
| 16. Round | 20/11/2021 | Sporting San Miguelito | - | Árabe Unido | 1:2 | |
Panama