| 1. Round | 20/07/2018 | Alianza Petrolera | - | La Equidad | 0:2 |  |
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| 2. Round | 31/07/2018 | Leones FC | - | Alianza Petrolera | 0:1 | ||||
| 3. Round | 06/08/2018 | Alianza Petrolera | - | Deportes Tolima | 4:2 | ||||
| 4. Round | 12/08/2018 | Santa Fe | - | Alianza Petrolera | 4:0 | ||||
| 5. Round | 18/08/2018 | Alianza Petrolera | - | Patriotas FC | 3:2 | |
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| 10. Round | 17/09/2018 | Alianza Petrolera | - | Atlético Bucaramanga | 1:2 | ||||
| 11. Round | 23/09/2018 | Deportivo Pasto | - | Alianza Petrolera | 2:1 | |
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| 12. Round | 30/09/2018 | Alianza Petrolera | - | Envigado FC | 1:2 | ||||
| 13. Round | 06/10/2018 | Atlético Huila | - | Alianza Petrolera | 2:1 | ||||
| 14. Round | 13/10/2018 | Alianza Petrolera | - | Boyacá Chicó | 1:0 | |
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| 15. Round | 18/10/2018 | Independiente Medellín | - | Alianza Petrolera | 2:0 | ||||
| 16. Round | 22/10/2018 | Alianza Petrolera | - | Deportivo Cali | 2:0 | ||||
| 17. Round | 28/10/2018 | Águilas Doradas | - | Alianza Petrolera | 1:0 | ||||
| 18. Round | 06/11/2018 | Alianza Petrolera | - | Atlético Junior | 0:3 | ||||
| 19. Round | 10/11/2018 | Once Caldas | - | Alianza Petrolera | 1:0 |
Guatemala