| 11. Round | 17/04/2021 | Sporting San Miguelito | - | Atlético Chiriquí | 2:1 | ||||
| 12. Round | 21/04/2021 | Sporting San Miguelito | - | Alianza | 0:0 |  |
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| 13. Round | 25/04/2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | ||||
| 14. Round | 28/04/2021 | Sporting San Miguelito | - | Tauro FC | 2:2 | ||||
| 15. Round | 06/05/2021 | Sporting San Miguelito | - | Deportivo del Este | 1:0 | ||||
| 16. Round | 08/05/2021 | Árabe Unido | - | Sporting San Miguelito | 1:2 |
Panama