| 18. Round | 29/01/2022 | KMSK Deinze | - | Excelsior Virton | 2:1 | ||||
| 19. Round | 04/02/2022 | Lierse Kempenzonen | - | KMSK Deinze | 1:1 | ||||
| 20. Round | 13/02/2022 | RWD Molenbeek | - | KMSK Deinze | 1:0 | ||||
| 21. Round | 20/02/2022 | KMSK Deinze | - | Lommel SK | 1:1 | ||||
| 22. Round | 26/02/2022 | Excelsior Virton | - | KMSK Deinze | 0:2 | ||||
| 23. Round | 04/03/2022 | KMSK Deinze | - | KVC Westerlo | 1:2 | ||||
| 24. Round | 13/03/2022 | KMSK Deinze | - | Waasland-Beveren | 3:3 | ||||
| 25. Round | 18/03/2022 | Royal Excel Mouscron | - | KMSK Deinze | 1:2 | ||||
| 26. Round | 03/04/2022 | KMSK Deinze | - | RWD Molenbeek | 3:0 | ||||
| 27. Round | 09/04/2022 | KMSK Deinze | - | Lierse Kempenzonen | 1:2 | ||||
| 28. Round | 16/04/2022 | Lommel SK | - | KMSK Deinze | 2:1 |  |
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