| 2. Round | 12/02/2022 | Ayacucho FC | - | Carlos Stein | 2:1 | ||||
| 3. Round | 20/02/2022 | Universidad Cesar Vallejo | - | Ayacucho FC | 2:1 | ||||
| 4. Round | 26/02/2022 | Ayacucho FC | - | Universidad San Martín | 5:0 |  |
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| 5. Round | 05/03/2022 | Cienciano | - | Ayacucho FC | 3:1 | ||||
| 6. Round | 13/03/2022 | Ayacucho FC | - | Deportivo Binacional | 2:3 | |
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| 7. Round | 20/03/2022 | AD Tarma | - | Ayacucho FC | 0:0 | ||||
| 8. Round | 01/04/2022 | Ayacucho FC | - | Universidad Técnica | 3:2 | |
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| 10. Round | 17/04/2022 | Sport Boys | - | Ayacucho FC | 1:0 | ||||
| 11. Round | 22/04/2022 | Ayacucho FC | - | Atlético Grau | 1:2 | ||||
| 13. Round | 08/05/2022 | Ayacucho FC | - | Mannucci | 2:2 | ||||
| 14. Round | 13/05/2022 | Sporting Cristal | - | Ayacucho FC | 3:2 | ||||
| 15. Round | 22/05/2022 | Ayacucho FC | - | FBC Melgar | 0:1 | ||||
| 17. Round | 20/06/2022 | Ayacucho FC | - | Sport Huancayo | 1:1 | |
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| 18. Round | 27/06/2022 | Alianza Lima | - | Ayacucho FC | 2:0 | ||||
| 19. Round | 01/07/2022 | Ayacucho FC | - | Academia Cantolao | 1:2 |
Peru