| 1. Round | 04/09/2022 | Imolese Calcio | - | US Alessandria 1912 | 1:0 | ||||
| 2. Round | 11/09/2022 | US Alessandria 1912 | - | Virtus Entella | 1:3 | ||||
| 4. Round | 19/09/2022 | US Alessandria 1912 | - | AC Reggiana 1919 | 0:2 |  |
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| 6. Round | 02/10/2022 | AC Rimini | - | US Alessandria 1912 | 3:0 | |
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| 7. Round | 09/10/2022 | US Alessandria 1912 | - | US Pontedera | 2:3 | |
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| 8. Round | 16/10/2022 | San Donato Tavarnelle | - | US Alessandria 1912 | 0:1 |  |
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| 9. Round | 19/10/2022 | US Alessandria 1912 | - | SEF Torres 1903 | 0:0 | |
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| 10. Round | 23/10/2022 | Vis Pesaro | - | US Alessandria 1912 | 0:0 | ||||
| 11. Round | 29/10/2022 | US Alessandria 1912 | - | US Recanatese | 0:1 | ||||
| 12. Round | 05/11/2022 | Lucchese | - | US Alessandria 1912 | 1:2 | ||||
| 15. Round | 26/11/2022 | US Fiorenzuola | - | US Alessandria 1912 | 0:0 | |
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| 17. Round | 03/12/2022 | Ancona 1905 | - | US Alessandria 1912 | 3:0 | |
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| 20. Round | 23/12/2022 | US Alessandria 1912 | - | Imolese Calcio | 2:0 | ||||
| 21. Round | 08/01/2023 | Virtus Entella | - | US Alessandria 1912 | 4:2 |
Romania