| 1. Round | 17/07/2021 | Gaz Metan Mediaş | - | CS Mioveni | 1:0 |  |
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| 2. Round | 25/07/2021 | Farul Constanța | - | Gaz Metan Mediaş | 2:0 | ||||
| 3. Round | 30/07/2021 | Gaz Metan Mediaş | - | Argeș Pitești | 2:2 | ||||
| 4. Round | 08/08/2021 | FCSB | - | Gaz Metan Mediaş | 2:1 | ||||
| 5. Round | 16/08/2021 | Gaz Metan Mediaş | - | FC Botoşani | 0:1 | ||||
| 7. Round | 30/08/2021 | Gaz Metan Mediaş | - | UTA Arad | 0:1 | ||||
| 13. Round | 22/10/2021 | FC Universitatea Craiova | - | Gaz Metan Mediaş | 2:0 | ||||
| 16. Round | 22/11/2021 | CS Mioveni | - | Gaz Metan Mediaş | 1:0 | ||||
| 18. Round | 06/12/2021 | Argeș Pitești | - | Gaz Metan Mediaş | 1:2 |
Italy