1. Round | 11/07/2022 | Diriangén FC | - | Matagalpa FC | 2:0 | ||||
2. Round | 17/07/2022 | Matagalpa FC | - | ART Municipal Jalapa | 0:0 | ||||
3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
4. Round | 31/07/2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 | ||||
5. Round | 07/08/2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
6. Round | 11/08/2022 | Matagalpa FC | - | CD Walter Ferretti | 1:0 | ||||
7. Round | 14/08/2022 | UNAN Managua | - | Matagalpa FC | 3:0 | ||||
8. Round | 21/08/2022 | Matagalpa FC | - | Managua FC | 1:0 | ||||
9. Round | 28/08/2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | ||||
10. Round | 04/09/2022 | Matagalpa FC | - | Diriangén FC | 2:3 | ||||
11. Round | 11/09/2022 | ART Municipal Jalapa | - | Matagalpa FC | 2:1 | ||||
12. Round | 01/10/2022 | Matagalpa FC | - | Juventus Managua | 2:5 | ||||
13. Round | 23/10/2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | ||||
14. Round | 27/10/2022 | Matagalpa FC | - | Club Deportivo Ocotal | 1:0 | ||||
15. Round | 30/10/2022 | CD Walter Ferretti | - | Matagalpa FC | 1:0 | ||||
16. Round | 23/11/2022 | Matagalpa FC | - | UNAN Managua | 3:3 | ||||
17. Round | 27/11/2022 | Managua FC | - | Matagalpa FC | 2:1 |