| 12. Round | 30/01/2021 | CD Marino | - | Algeciras CF | 1:1 | ||||
| 13. Round | 07/02/2021 | UD Tamaraceite | - | CD Marino | 2:1 | ||||
| 14. Round | 13/02/2021 | CD Marino | - | Cádiz CF B | 0:0 | ||||
| 15. Round | 21/02/2021 | Atlético Sanluqueño CF | - | CD Marino | 2:0 | ||||
| 16. Round | 06/03/2021 | CD Marino | - | Recreativo Huelva | 2:1 | ||||
| 17. Round | 14/03/2021 | UD Las Palmas B | - | CD Marino | 2:1 | ||||
| 18. Round | 21/03/2021 | CD Marino | - | San Fernando CD | 0:1 |
Colombia