| 1. Round | 30/07/2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Round | 06/08/2022 | River Plate | - | Plaza Colonia | 2:0 | ||||
| 3. Round | 12/08/2022 | Plaza Colonia | - | Cerro Largo | 2:0 | ||||
| 6. Round | 22/08/2022 | Albion | - | Plaza Colonia | 1:0 |  |
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| 8. Round | 13/09/2022 | Danubio | - | Plaza Colonia | 1:1 | ||||
| 9. Round | 17/09/2022 | Plaza Colonia | - | Deportivo Maldonado | 0:1 | ||||
| 11. Round | 01/10/2022 | Plaza Colonia | - | Liverpool | 1:3 | ||||
| 12. Round | 09/10/2022 | Peñarol | - | Plaza Colonia | 0:1 | ||||
| 14. Round | 17/10/2022 | Montevideo Wanderers | - | Plaza Colonia | 2:1 | |
Guatemala