| 2. Round | 17/01/2021 | CS Cartaginés | - | Guadalupe | 2:1 |  |
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| 3. Round | 22/01/2021 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | |
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| 4. Round | 24/01/2021 | CS Cartaginés | - | Limón FC | 1:1 | ||||
| 5. Round | 31/01/2021 | Deportivo Saprissa | - | CS Cartaginés | 4:1 | ||||
| 6. Round | 04/02/2021 | AD San Carlos | - | CS Cartaginés | 1:1 | |
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| 7. Round | 07/02/2021 | CS Cartaginés | - | CS Herediano | 1:2 | ||||
| 8. Round | 13/02/2021 | Sporting FC | - | CS Cartaginés | 3:1 | ||||
| 9. Round | 21/02/2021 | CS Cartaginés | - | LD Alajuelense | 1:1 | |
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| 10. Round | 27/02/2021 | Municipal Grecia | - | CS Cartaginés | 1:2 | ||||
| 12. Round | 09/03/2021 | Santos de Guápiles | - | CS Cartaginés | 1:0 | ||||
| 13. Round | 13/03/2021 | Guadalupe | - | CS Cartaginés | 0:3 | |
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| 14. Round | 20/03/2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 0:0 | ||||
| 15. Round | 31/03/2021 | Limón FC | - | CS Cartaginés | 1:1 | |
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| 16. Round | 04/04/2021 | CS Cartaginés | - | Deportivo Saprissa | 0:0 |  |
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| 20. Round | 25/04/2021 | LD Alajuelense | - | CS Cartaginés | 4:1 | ||||
| 21. Round | 01/05/2021 | CS Cartaginés | - | Municipal Grecia | 2:0 | |
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| 22. Round | 13/05/2021 | Jicaral | - | CS Cartaginés | 1:0 |
Honduras